• Recommendations for the development, implementation, and reporting of control interventions in efficacy and mechanistic trials of physical, psychological, and self-management therapies: the CoPPS Statement 

      Hohenschurz-Schmidt, David; Vase, Lene; Scott, Whitney; Annoni, Marco; Ajayi, Oluwafemi K; Barth, Jürgen; Bennell, Kim; Berna, Chantal; Bialosky, Joel; Braithwaite, Felicity; Finnerup, Nanna B.; de C Williams, Amanda C; carlino, elisa; Ceritelli, Francesco; Chaibi, Aleksander; Cherkin, Dan; Colloca, Luana; Cote, Pierre; Darnall, Beth D; Evans, Roni; Fabre, Laurent; Faria, Vanda; French, Simon D; Gerger, Heike; Häuser, Winfried; Hinman, Rana S.; Ho, Dien; Janssens, Thomas; Jensen, Karin; Johnston, Chris; Juhl Lunde, Sigrid; Keefe, Francis; Kerns, Robert D; Koechlin, Helen; Kongsted, Alice; Michener, Lori A; Moerman, Daniel E; Musial, Frauke; Newell, David; Nicholas, Michael; Palermo, Tonya M; Palermo, Sara; Peerdeman, Kaya J.; Pogatzky-Zahn, Esther M; Puhl, Aaron A; Roberts, Lisa; Rossettini, Giacomo; Tomczak Matthiesen, Susan; Underwood, Martin; Vaucher, Paul; Vollert, Jan; Wartolowska, Karolina; Weimer, Katja; Werner, Christoph Patrick; Rice, Andrew S C; Draper-Rodi, Jerry (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-25)
      Control interventions (often called “sham,” “placebo,” or “attention controls”) are essential for studying the efficacy or mechanism of physical, psychological, and self-management interventions in clinical trials. This article presents core recommendations for designing, conducting, and reporting control interventions to establish a quality standard in non-pharmacological intervention research. A ...
    • The serotonin receptor 2A (HTR2A) rs6313 variant is associated with higher ongoing pain and signs of central sensitization in neuropathic pain patients 

      Sachau, Juliane; Bruckmüller, Henrike; Gierthmühlen, Janne; Magerl, Walter; May, Denisa; Forstenpointner, Julia; Koetting, Judith; Maier, Christoph; Tölle, Thomas R.; Treede, Rolf-Detlef; Berthele, Achim; Caliebe, Amke; Diesch, Carolin; Flor, Herta; Huge, Volker; Maihöfner, Christian; Rehm, Stefanie; Kersebaum, Dilara; Fabig, Sophi-Charlotte; Vollert, Jan; Rolke, Roman; Stemmler, Susanne; Sommer, Claudia; Westermann, Andrea; Cascorbi, Ingolf; Baron, Ralf (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-10)
      <p>Background - The serotonin receptor 2A (HTR2A) has been described as an important facilitation mediator of spinal nociceptive processing leading to central sensitization (CS) in animal models of chronic pain. However, whether HTR2A single nucleotide variants (SNVs) modulate neuropathic pain states in patients has not been investigated so far. The aim of this study was to elucidate the potential ...